Crystallization Expert Delivering Worldwide 1 or 2-day Customizable

Crystallization and Polymorphism Workshops

 

Understanding crystallization can help:

• Select the best crystallization mode

• Maximize process yield

• Achieve and improve purity

• Control polymorphic form, crystal morphology, and particle size distribution

• Develop optimal processes suitable for scale-up

• Improve on existing process

• Reduce overall cost

• Foster safety

• Establish alternatives 

• Enable solid form life cycle management     

• Strengthen defensive and offensive IP

 

SAMPLE AGENDA OF 1 or 2-DAY CRYSTALLIZATION AND POLYMORPHISM WORKSHOP

with principal focus on active pharmaceutical ingredients (APIs)

 

FUNDAMENTALS OF CRYSTALLIZATION

• Supersaturation, Metastable Zone, Metastable Zone Width

• Mechanism of Nucleation and Crystal Growth

• Kinetics of Nucleation and Crystal Growth

 

CRYSTAL FORMS

• Polymorphs and Solvatomorphs: Expected Unexpected

• Salts and Cocrystals

• Physicochemical Characterization of Crystalline Materials

 

CRYSTALLIZATION PROCESSES

• Modes of Crystallization (cooling, reactive crystallization, evaporation, antisolvent addition)

• Crystallization from Solution

• Batch (main focus) and Continuous Process

• Unseeded vs. Seeded Batch Crystallization

• PAT Tools

 

CASE STUDY EXAMPLES

• Batch Reactive Crystallization

• Crystal Size Manipulation

• Polymorphs Behaving Badly

• Targeting Right Polymorph

• Targeting Right Salt Stoichiometry

• Elucidation of Unusual Observations

 

TIPS AND HINTS

 

Q&A