​CRYSTALLIZATION EXPERT CONSULTING SERVICES 

Crystallization expert, consultant, specialist, troubleshooter, and speaker specializing in crystallization and precipitation processes

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• Academic Experience (15 Years) – Taught chemical engineering at Wroclaw University of Science and Technology (Poland), Iowa State University (US), and Worcester Polytechnic Institute (US).

• Scientist at Eastman Kodak (14 Years) – Engineered novel submicron-sized AgX crystalline forms and pioneered nanosized pharmaceutical crystal development for Sterling Winthrop.

• Leadership at Novartis (14 Years) – Led both the Salt & Polymorphism and Particle Engineering networks. Oversaw salt, cocrystal, and polymorphic form selection for API development, API property characterization, crystal and particle engineering, and optimization/scale-up of API crystallization processes. Supervised 280+ API projects, investigating 850+ polymorphs and solvatomorphs.

• Publications & Patents – Authored/co-authored two monographs, ten book chapters, 28 patents, 40+ refereed papers, and 100+ conference presentations. Examples of publications as crystallization expert:

  • Karpinski, PH., Wey, J.S., Chapter 6: Precipitation Processes in “Handbook of Industrial Crystallization (Second Edition),” Butterworth Heinemann, Boston 2002 (ed. by A.S. Myerson), pp. 141-160

  • Wey, J.S., Karpinski P.H., Chapter 10: Batch Crystallization in “Handbook of Industrial Crystallization, Second Edition)” Butterworth Heinemann, Boston 2002 (ed. by A.S. Myerson), pp. 231-248

  • Karpinski P. H., Chapter 9: Large-Scale Aspects of API Salt Manufacture, in “Handbook of Pharmaceutical Salts,” 2nd edition, P.H. Stahl & C.G. Wermuth, Eds., Wiley-VCH, Zurich 2011, pp. 234-269

  • Karpinski P. H., Baldyga J., Chapter 8: Precipitation Processes in “Handbook of Industrial Crystallization (3rd revised and enlarged edition),” Cambridge University Press, New York 2019 (ed. by A.S. Myerson, A. Lee and D. Erdemir), pp. 231-248

  • Karpinski P. H., Baldyga J., Chapter 12: Batch Crystallization in “Handbook of Industrial 2 Crystallization (3rd revised and enlarged edition),” Cambridge University Press, New York 2019 (ed. by A.S. Myerson, A. Lee and D. Erdemir), pp. 346-379

• Innovative Contributions – E.g., Co-invented and led the early development of two crystalline APIs, Tasigna® and Entresto®, which now generate over $6 billion in annual revenue.